Tracer library / [18F]FHBG
[18F]FHBG
Also written as 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine; [18F]FHBG; [F-18]FHBG; FHBG
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 6
What it is
- Compound class
- Radiolabelled acycloguanosine analogue (PET reporter probe)
- Target / mechanism
- Herpes simplex virus type 1 thymidine kinase (HSV1-tk) / mutant HSV1-sr39tk enzyme — phosphorylation-dependent intracellular trapping PMID 17406570
- Clinical application
- PET reporter-gene imaging of HSV1-tk-transduced cells (gene-therapy vector tracking) PMID 17406570
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| ELIXYS FLEX/CHEM Sofie | — | HPLC | — | — | — | 28443841 2017 Lab Chip synthesized using the ELIXYS radiosynthesizer (Sofie Biosciences, Culver City, CA, USA) |
| Explora GN Siemens / CTI | — | HPLC | 40 | 96 | — | 22172393 2012 Nucl Med Biol automated them on an Explora General Nucleophilic double-synthesis module - competitive radiochemical yields of up to 40% in an overall synthesis time of 60±10 min |
| TRACERlab FX FN GE HealthCare | — | SPE | 8-14% not corrected | >99% | tosylate precursor | 20032804 2010 Nucl Med Commun A TRACERlab FXF-N synthesizer was substantially modified and adapted to the synthesis of [F]FHBG through the two-step one-pot procedure. - The decay-uncorrected radiochemical yield of [F]FHBG was 8-14% (n=10) |
| TRACERlab MX GE HealthCare | — | HPLC | 21.0±3.8% | 98±0.9% | — | 19553130 2009 Appl Radiat Isot Tracerlab MX - Synthesis using the Tracerlab MX module showed a 21.0+/-3.8% yield of radiochemical |
| Explora RN Siemens / CTI | — | HPLC | 32.0±1.2% | 99.0±0.6% | — | 19553130 2009 Appl Radiat Isot Explora RN - synthesis using the Explora RN module showed a 32.0+/-1.2% yield of radiochemical |
| Nuclear Interface Nuclear Interface (legacy) | — | HPLC+SPE | 10-15% | >99% | tosylate precursor | 14537106 2002 Mol Imaging Biol A nuclear interface commercial synthesizer was substantially modified and adapted to the synthesis of the referred compound. - [18F]FHBG was obtained in 10-15% yield in 65 minutes including HPLC purification. |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FHBG.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.