Tracers / [18F]FHBG
[18F]FHBG
Also written as 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine; [18F]FHBG; [F-18]FHBG; FHBG
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 6
What it is
- Compound class
- Radiolabelled acycloguanosine analogue (PET reporter probe)
- Target / mechanism
- Herpes simplex virus type 1 thymidine kinase (HSV1-tk) / mutant HSV1-sr39tk enzyme — phosphorylation-dependent intracellular trapping PMID 17406570
- Clinical application
- PET reporter-gene imaging of HSV1-tk-transduced cells (gene-therapy vector tracking) PMID 17406570
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
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- Brand names
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Clinical use
- Typical injected activity
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- Uptake time
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Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| ELIXYS FLEX/CHEM Sofie Biosciences | — | HPLC | — | — | — | 28443841 2017 Lab Chip synthesized using the ELIXYS radiosynthesizer (Sofie Biosciences, Culver City, CA, USA) |
| — | — | HPLC | 40 | 96 | — | 22172393 2012 Nucl Med Biol automated them on an Explora General Nucleophilic double-synthesis module — competitive radiochemical yields of up to 40% in an overall synthesis time of 60±10 min |
| — | — | SPE | 8-14% no | more than 99% | tosylate precursor | 20032804 2010 Nucl Med Commun A TRACERlab FXF-N synthesizer was substantially modified and adapted to the synthesis of [F]FHBG through the two-step one-pot procedure. — The decay-uncorrected radiochemical yield of [F]FHBG was 8-14% (n=10) |
| — | — | HPLC | 21.0±3.8% | 98±0.9% | — | 19553130 2009 Appl Radiat Isot Tracerlab MX — Synthesis using the Tracerlab MX module showed a 21.0+/-3.8% yield of radiochemical |
| — | — | HPLC | 32.0±1.2% | 99.0±0.6% | — | 19553130 2009 Appl Radiat Isot Explora RN — synthesis using the Explora RN module showed a 32.0+/-1.2% yield of radiochemical |
| — | — | HPLC+SPE | 10-15% | >99% | tosylate precursor | 14537106 2002 Mol Imaging Biol A nuclear interface commercial synthesizer was substantially modified and adapted to the synthesis of the referred compound. — [18F]FHBG was obtained in 10-15% yield in 65 minutes including HPLC purification. |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FHBG.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.