Tracer library / [18F]FGln

Structure of fluoroglutamine (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 87214873

[18F]FGln

Also written as [18F]FGln; [18F]fluoroglutamine; [F-18]FGln; [F-18]fluoroglutamine; fluoroglutamine

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 3

What it is

Compound class: Radiolabeled glutamine analogue (fluorinated glutamine derivative)
Target / mechanism: —
Clinical application: —
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX N Pro GE HealthCare	custom manifold	HPLC+SPE	21 ± 3% not corrected	>98%	tosylate precursor 2,…tosylate precursor 2, tert-butyl-(2S,4S)-2-((tert-butoxycarbonyl)amino)-5-oxo-4-(tosyloxy)-5-((2,4,6-trimethoxybenzyl)amino)pentanoate	27019029 2016 Appl Radiat Isot Automated Synthesis of [18F](2S,4R)-4-fluoroglutamine on a GE FX-N Pro Module - [18F]FGln was obtained in 80 min with a radiochemical yield of 21 ± 3% (n = 5, uncorrected).
AllinOne (AiO) Trasis	vendor cassette	HPLC+SPE	11 ± 3 decay-corrected	≥90%	[18F]F-Gln tosylate precursor MSKCCC (New York, USA) or from Dr. Hank Kung	29564391 2017 EJNMMI Radiopharm Chem AllinOne synthesis module - [18F]F-Gln2511 ± 3>40b 98Two vessels, two steps, HPLC, SPE
PET-MF-2V-IT-1 vendor not confirmed -- see article	—	—	18.0 ± 4.2% decay-corrected	>90%	—	30861162 2019 J Labelled Comp Radiopharm [18 F]FGln was prepared by a fully automated PET-MF-2V-IT-I synthesizer under GMP-compliant conditions for routine clinical studies. - the decay-corrected radiochemical yield was 18.0 ± 4.2% (n = 59; failure n = 15)

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: MSKCCC (New York, USA) or from Dr. Hank Kung
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 29564391: '(2S, 4R)-tert-butyl-2-(tert-butoxycarbonylamino)-5-oxo-4-(tosyloxy)-5-(2, 4, 6-trimethoxybenzylamino)pentanoate'.