Tracers / [18F]FGln
[18F]FGln
Also written as [18F]FGln; [18F]fluoroglutamine; [F-18]FGln; [F-18]fluoroglutamine; fluoroglutamine
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
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- Syntheses indexed
- 2
What it is
- Compound class
- Radiolabeled glutamine analogue (fluorinated glutamine derivative)
- Target / mechanism
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- Clinical application
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- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
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- Brand names
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Clinical use
- Typical injected activity
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- Uptake time
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Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | vendor cassette | HPLC+SPE | 11 ± 3 yes | ≥90% | [18F]F-Gln tosylate precursor MSKCCC (New York, USA) or from Dr. Hank Kung | 29564391 2017 EJNMMI Radiopharm Chem AllinOne synthesis module — [18F]F-Gln2511 ± 3>40b 98Two vessels, two steps, HPLC, SPE |
| — | — | — | 18.0 ± 4.2% yes | greater than 90% | — | 30861162 2019 J Labelled Comp Radiopharm [18 F]FGln was prepared by a fully automated PET-MF-2V-IT-I synthesizer under GMP-compliant conditions for routine clinical studies. — the decay-corrected radiochemical yield was 18.0 ± 4.2% (n = 59; failure n = 15) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FGln.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 29564391: '(2S, 4R)-tert-butyl-2-(tert-butoxycarbonylamino)-5-oxo-4-(tosyloxy)-5-(2, 4, 6-trimethoxybenzylamino)pentanoate'.