Tracer library / [18F]FEAU

[18F]FEAU

Also written as [18F]FEAU; [F-18]FEAU

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Reporter gene imaging

What it is

Compound class: radiolabeled pyrimidine nucleoside analogue
Target / mechanism: Substrate for HSV1-tk/sr39tk enzyme, trapped intracellularly after phosphorylation, enabling reporter gene imaging PMID 18157580
Clinical application: PET imaging of HSV1-tk/sr39tk reporter gene expression PMID 18157580
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN	—	HPLC	5±1% decay-corrected	99%	—	18157580 2008 Mol Imaging Biol a commercial GE TRACERlab FX-FN radiosynthesis module with customized equipment - afforded purified [18F]FEAU β-anomer in 5±1% overall yield (n=3 runs)
ELIXYS FLEX/CHEM Sofie	—	HPLC	—	—	—	28443841 2017 Lab Chip synthesized using the ELIXYS radiosynthesizer (Sofie Biosciences, Culver City, CA, USA)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.