Tracers / [18F]FEAU
[18F]FEAU
Also written as [18F]FEAU; [F-18]FEAU
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- radiolabeled pyrimidine nucleoside analogue
- Target / mechanism
- Substrate for HSV1-tk/sr39tk enzyme, trapped intracellularly after phosphorylation, enabling reporter gene imaging PMID 18157580
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX FN | — | HPLC | 5±1% yes | 99% | — | 18157580 2008 Mol Imaging Biol a commercial GE TRACERlab FX-FN radiosynthesis module with customized equipment — afforded purified [18F]FEAU β-anomer in 5±1% overall yield (n=3 runs) |
| ELIXYS FLEX/CHEM Sofie Biosciences | — | HPLC | — | — | — | 28443841 2017 Lab Chip synthesized using the ELIXYS radiosynthesizer (Sofie Biosciences, Culver City, CA, USA) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FEAU.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18.