Tracer library / [18F]FBEM
[18F]FBEM
Also written as 4-[18F]fluorobenzamido-N-ethylamino-maleimide; [18F]FBEM; [F-18]FBEM; F-18 FBEM; FBEM
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Research
- Syntheses indexed
- 3
What it is
- Compound class
- Maleimide conjugate
- Target / mechanism
- Thiol-reactive (maleimide) 18F-prosthetic group; site-specific conjugation to free cysteine thiols; no biological target PMID 16818952 / PMC1704081
- Clinical application
- Site-specific 18F-labelling of thiol-bearing peptides and proteins PMID 16818952 / PMC1704081
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=fluorobenzamido+maleimide
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX N Pro GE HealthCare | custom manifold | HPLC+SPE | 7.5-18.8 not corrected | >98 | 4-(ethoxycarbonyl)-N,N,N-trimethylbenzenamin…4-(ethoxycarbonyl)-N,N,N-trimethylbenzenaminium trifluoromethanesulfonate | 30098587 2018 Appl Radiat Isot Synthesis of [18F]FBEM was carried out with a TRACERLab™ FXNPro module from GE Healthcare (Milwaukee, WI). - 7.5–18.8% non-decay corrected yield |
| ELIXYS FLEX/CHEM Sofie | — | HPLC | — | — | — | 28443841 2017 Lab Chip Synthesis of N-[2-(4-[18F]fluorobenzamido)ethyl]maleimide ([18F]FBEM) was synthesized on the ELIXYS radiosynthesizer |
| iPHASE FlexLab iPHASE Technologies | — | HPLC | 15-20% decay-corrected | 97 ± 1% | — | 24395455 2014 J Labelled Comp Radiopharm using a slightly modified iPHASE FlexLab module - [(18) F]FBEM was produced in 1.185 ± 0.168 GBq (15-20%; n = 10; 0.75 ± 0.106 GBq non-decay corrected) |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Typical final purification
- HPLC
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Conjugation reagent rather than a standalone tracer.