Tracers / [11C]TGN-020
[11C]TGN-020
Also written as [11C]TGN-020; [C-11]TGN-020
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- Aquaporin-4 (AQP4) inhibitor, nicotinic acid-thiadiazole derivative
- Target / mechanism
- Aquaporin-4 (AQP4) PMID 40186669
- Clinical application
- —
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| In-house / custom built in-house | custom manifold | HPLC | 2.8 ± 0.7% | > 95% | 3-bromopyridine Tokyo Chemical Industry, Tokyo, Japan | 40186669 2025 EJNMMI Radiopharm Chem [11C]TGN-020 was synthesized using an automated multi-purpose radiosynthesis apparatus developed in-house (Kawamura et al. 2019). — achieving a high radiochemical yield based on [11C]CO2 (610‒1700 MBq, 2.8 ± 0.7%) at the end of synthesis (n = 12) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]TGN-020.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with C-11.