Tracer library / [11C]TGN-020

Structure of TGN-020 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 4173511

[11C]TGN-020

Also written as [11C]TGN-020; [C-11]TGN-020

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

What it is

Compound class: Aquaporin-4 (AQP4) inhibitor, nicotinic acid-thiadiazole derivative
Target / mechanism: Aquaporin-4 (AQP4) PMID 40186669
Clinical application: Brain imaging of aquaporin-4 in clinical studies PMID 40186669
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
In-house / custom built in-house	custom manifold	HPLC	2.8 ± 0.7%	> 95%	3-bromopyridine Tokyo Chemical Industry, Tokyo, Japan	40186669 2025 EJNMMI Radiopharm Chem [11C]TGN-020 was synthesized using an automated multi-purpose radiosynthesis apparatus developed in-house (Kawamura et al. 2019). - achieving a high radiochemical yield based on [11C]CO2 (610‒1700 MBq, 2.8 ± 0.7%) at the end of synthesis (n = 12)

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Tokyo Chemical Industry
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with C-11.