Tracer library / [11C]raclopride

Structure of raclopride (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 3033769

[11C]raclopride

Also written as [11C]Raclopride; [C-11]Raclopride; Raclopride

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 4

CNS receptor and transporter imaging

What it is

Compound class: substituted benzamide (raclopride, desmethyl-raclopride precursor)
Target / mechanism: Dopamine D2/D3 receptor antagonist radiotracer PMID 26058690
Clinical application: PET imaging of striatal dopamine D2/D3 receptor availability in healthy humans PMID 26058690
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX C Pro GE HealthCare	custom manifold	HPLC	3.7% not corrected	>95%	desmethyl-raclopride TBA salt ABX	23123138 2013 Nucl Med Biol Ethanolic loop chemistry is fully automated using a GE TRACERLab FXC-Pro synthesis module - 3.7% RCY; >95% RCP; SA = 20831 Ci/mmol; n = 64
TRACERlab FX C Pro GE HealthCare	—	—	51.3 ± 11.2 decay-corrected	>99%	(S)-O-desmethylraclopride	21897309 2011 Nucl Med Commun [\u00b9\u00b9C]methyl iodide and [\u00b9\u00b9C]methyl triflate were produced in the TRACERlab FXC Pro synthesis box. Methylation reactions and the final formulation were performed using the AutoLoop (captive solvent method) and the ReFORM-plus systems, respectively. - Good radiochemical yields (51.3 \u00b1 11.2 and 32.9 \u00b1 6.6%, referred to as [\u00b9\u00b9C]methyl iodide, decay corrected)
Synthra GPextent Synthra	—	—	4±2% not corrected	>95%	—	25335809 2014 Curr Radiopharm using a Synthra GPextent system - 4±2% (ndc) yield of [(11)C]Raclopride
TRACERlab FX C Pro GE HealthCare	—	—	30% decay-corrected	>95%	—	19162491 2009 Appl Radiat Isot A simple modification of GE tracerlab FX C Pro for rapid sequential preparation of [11C]carfentanil and [11C]raclopride. - The radiochemical yields were over 40% and 30% (decay-corrected and based on [(11)C]methyl iodide) for [(11)C]carfentanil and [(11)C]raclopride, respectively.

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: ABX
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 23123138: 'desmethyl-raclopride TBA salt (1 mg)'.