Tracers / [11C]raclopride
[11C]raclopride
Also written as [11C]Raclopride; [C-11]Raclopride; Raclopride
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 7
What it is
- Compound class
- substituted benzamide (raclopride, desmethyl-raclopride precursor)
- Target / mechanism
- Dopamine D2/D3 receptor antagonist radiotracer PMID 26058690
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX C Pro GE HealthCare | custom manifold | HPLC | 3.7% no | >95% | desmethyl-raclopride TBA salt ABX | 23123138 2013 Nucl Med Biol Ethanolic loop chemistry is fully automated using a GE TRACERLab FXC-Pro synthesis module — 3.7% RCY; >95% RCP; SA = 20831 Ci/mmol; n = 64 |
| — | — | — | — | — | — | 26058690 2015 J Cereb Blood Flow Metab |
| — | — | — | — | — | — | 37513867 2023 Pharmaceuticals (Basel) |
| — | — | — | 50 ± 5 | — | — | 37513867 2023 Pharmaceuticals (Basel) |
| — | — | — | 51.3 ± 11.2 yes | >99% | (S)-O-desmethylraclopride | 21897309 2011 Nucl Med Commun [\u00b9\u00b9C]methyl iodide and [\u00b9\u00b9C]methyl triflate were produced in the TRACERlab FXC Pro synthesis box. Methylation reactions and the final formulation were performed using the AutoLoop (captive solvent method) and the ReFORM-plus systems, respectively. — Good radiochemical yields (51.3 \u00b1 11.2 and 32.9 \u00b1 6.6%, referred to as [\u00b9\u00b9C]methyl iodide, decay corrected) |
| — | — | — | 4±2% no | >95% | — | 25335809 2014 Curr Radiopharm using a Synthra GPextent system — 4±2% (ndc) yield of [(11)C]Raclopride |
| — | — | — | 30% yes | greater than 95% | — | 19162491 2009 Appl Radiat Isot A simple modification of GE tracerlab FX C Pro for rapid sequential preparation of [11C]carfentanil and [11C]raclopride. — The radiochemical yields were over 40% and 30% (decay-corrected and based on [(11)C]methyl iodide) for [(11)C]carfentanil and [(11)C]raclopride, respectively. |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]raclopride.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 23123138: 'desmethyl-raclopride TBA salt (1 mg)'.