Tracer library / [11C]MTP38

Structure of MTP38 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 157010704

[11C]MTP38

Also written as [11C]MTP38; [C-11]MTP38

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 1

CNS receptor and transporter imaging

What it is

Compound class: PET ligand (radiolabeled phosphodiesterase 7 inhibitor, triazolopyrazine carbonitrile derivative)
Target / mechanism: Phosphodiesterase 7 (PDE7) PMID 33674894
Clinical application: Healthy male volunteers; investigation of neuropsychiatric diseases involving PDE7 dysfunction PMID 33566152
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
In-house / custom built Laboratory	—	—	33 ± 5.5% decay-corrected	>97%	—	35122288 2022 J Labelled Comp Radiopharm Radiosynthesis of [11 C]MTP38 was performed using an automated 11 C-labeling synthesizer developed in-house within 40 min after the end of irradiation. - relatively high radiochemical yield (33 ± 5.5% based on [11 C]CO2 at the end of irradiation, decay-corrected, n = 15)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with C-11. | Stage 30 (2026-09-18): Stage was 'first-in-human'; normalised to 'Clinical research', original wording kept here.