Tracers / [11C]FMZ
[11C]FMZ
Also written as [11C]flumazenil; [11C]FMZ; [C-11]flumazenil; [C-11]FMZ; Flumazenil
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- flumazenil derivative (desmethyl flumazenil precursor)
- Target / mechanism
- Benzodiazepine receptor ligand PMID 36557975
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| iMiDEV PMB-Alcen | custom manifold | HPLC+SPE | 22-28% (RCC) | >99.00% | desmethyl flumazenil PharmaSynth AS, Tartu, Estonia | 36557975 2022 Molecules iMiDEV™ Automated Microfluidic Radiosynthesizer — The yield of radiochemical conversion for [11C]flumazenil and [11C]deprenyl was 22–28%. |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]FMZ.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 36557975: 'desmethyl flumazenil (precursor) and flumazenil (reference standard) were procured from Pharmasynth AS, Tartu, Estonia'.