Tracer library / [11C]FMZ

Structure of flumazenil (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 3373

[11C]FMZ

Also written as [11C]flumazenil; [11C]FMZ; [C-11]flumazenil; [C-11]FMZ; Flumazenil

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

What it is

Compound class: flumazenil derivative (desmethyl flumazenil precursor)
Target / mechanism: Benzodiazepine receptor ligand PMID 36557975
Clinical application: —
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
iMiDEV PMB-Alcen	custom manifold	HPLC+SPE	22-28% RCC	>99.00%	desmethyl flumazenil PharmaSynth AS, Tartu, Estonia	36557975 2022 Molecules iMiDEV™ Automated Microfluidic Radiosynthesizer - The yield of radiochemical conversion for [11C]flumazenil and [11C]deprenyl was 22–28%.

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: PharmaSynth AS
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 36557975: 'desmethyl flumazenil (precursor) and flumazenil (reference standard) were procured from Pharmasynth AS, Tartu, Estonia'.