Tracer library / [11C]evobrutinib

Structure of evobrutinib (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 71479709

[11C]evobrutinib

Also written as [11C]Evobrutinib; [C-11]Evobrutinib

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 3

Infection imaging Inflammatory disease Gastrointestinal and colorectal cancer

What it is

Compound class: Bruton's tyrosine kinase (BTK) inhibitor
Target / mechanism: Bruton's tyrosine kinase inhibitor PMID 39831838
Clinical application: In vivo imaging of BTK in disease models including colorectal cancer, SARS-CoV-2 infection, and LPS-induced lung damage PMID 37691152
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX (model not stated) GE HealthCare	—	HPLC	—	—	—	37513867 2023 Pharmaceuticals (Basel) a modified GE TracerLabTM synthesis platform - three clinically relevant BTK inhibitors, [11C]ibrutinib, [11C]tolebrutinib, and [11C]evobrutinib, were synthesized at good RCYs
TracerMaker Scansys Laboratorieteknik	—	HPLC	4 not corrected	—	—	39831838 2025 ChemistryOpen was delivered to a TracerMaker synthesis platform (Scansys Laboratorieteknik, Denmark) - [11C]evobrutinib in RCY of 4 % an Am of 25.3 GBq/μmol
—	—	—	5.5 ± 1.5%	99%	—	37691152 2024 J Labelled Comp Radiopharm

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with C-11. Stage set/updated at stage 39 from PMID 37691152: 'Ex vivo autoradiography studies showed high specific binding of [11C]evobrutinib in HT-29 colorectal cancer mouse xenograft tissues (51.1 ± 7.1%).'.