:root{
  --bg:#ECEFF1; --surface:#fff; --ink:#10212B; --muted:#5C6B73; --line:#CBD5D9;
  --steel:#2B5A74; --steel-d:#1D4256; --wash:#E1E7EA;
  --brass:#B08423; --oxide:#A8432A; --patina:#3E7A6B; --bronze:#8A6B33; --slate:#35576E; --lead:#6B7076;
}
*{box-sizing:border-box}
html,body{margin:0;padding:0}
body{background:var(--bg);color:var(--ink);font-family:"IBM Plex Sans",system-ui,sans-serif;font-size:16px;line-height:1.55;-webkit-font-smoothing:antialiased}
a{color:var(--steel);text-decoration:none}
a:hover{text-decoration:underline}
code,.mono{font-family:"IBM Plex Mono",ui-monospace,monospace}
:focus-visible{outline:2px solid var(--steel);outline-offset:2px}
.wrap{max-width:1120px;margin:0 auto;padding:0 24px}

/* header */
header{background:var(--ink);color:#DDE5E9;position:sticky;top:0;z-index:40}
.hin{max-width:1120px;margin:0 auto;padding:0 24px;display:flex;align-items:center;gap:28px;height:56px}
.logo{font-weight:600;letter-spacing:.01em;color:#fff;font-size:18px}
.logo span{color:var(--brass);font-weight:700}
nav.top{display:flex;gap:20px;font-size:14.5px;margin-left:auto;flex-wrap:wrap}
nav.top a{color:#AFBEC6}
nav.top a.on{color:#fff;box-shadow:inset 0 -2px 0 var(--brass)}

/* hero */
.hero{background:var(--surface);border-bottom:1px solid var(--line)}
.hero .wrap{padding-top:52px;padding-bottom:40px}
h1.big{font-size:clamp(30px,4.2vw,46px);line-height:1.1;margin:0 0 14px;font-weight:600;max-width:20ch}
.lede{font-size:18px;color:var(--muted);max-width:62ch;margin:0 0 30px}
.searchbox{display:flex;border:1.5px solid var(--ink);background:#fff}
.searchbox input{flex:1;border:0;padding:15px 16px;font:inherit;font-size:17px;background:transparent}
.searchbox input:focus{outline:none}
.searchbox button{border:0;background:var(--ink);color:#fff;padding:0 24px;font:inherit;font-weight:600;cursor:pointer}

/* isotope strip */
.strip{margin-top:34px}
.strip .bar{display:flex;height:38px;border:1px solid var(--line)}
.strip .seg{position:relative;cursor:pointer;display:flex;align-items:center;justify-content:center;color:#fff;font-size:12.5px;font-weight:600;min-width:3px;transition:filter .12s}
.strip .seg:hover{filter:brightness(1.18)}
.strip .cap{display:flex;justify-content:space-between;font-size:13px;color:var(--muted);margin-top:8px}

/* doors */
.doors{display:grid;grid-template-columns:repeat(3,1fr);gap:1px;background:var(--line);border:1px solid var(--line);margin:40px 0 0}
.door{background:var(--surface);padding:26px 24px 24px;display:block;color:inherit}
.door:hover{background:#F7F9FA;text-decoration:none}
.door h3{margin:0 0 8px;font-size:19px;font-weight:600}
.door p{margin:0 0 14px;color:var(--muted);font-size:14.5px;line-height:1.5}
.door .go{font-size:14px;color:var(--steel);font-weight:600}
.door .who{font-size:12.5px;color:var(--lead);border-top:1px solid var(--line);padding-top:10px;margin-top:14px}

main{padding:36px 0 60px}
h2.sec{font-size:26px;margin:0 0 6px;font-weight:600}
.sub{color:var(--muted);margin:0 0 24px;font-size:15px}

/* filters */
.filters{display:flex;gap:8px;flex-wrap:wrap;margin-bottom:18px;align-items:center}
.chip{border:1px solid var(--line);background:var(--surface);padding:6px 12px;font:inherit;font-size:13.5px;cursor:pointer;color:var(--muted);text-decoration:none;display:inline-block}
.chip.on{background:var(--ink);color:#fff;border-color:var(--ink)}
.fsearch{border:1px solid var(--line);padding:7px 12px;font:inherit;font-size:14px;min-width:220px;background:var(--surface)}

/* table */
table{width:100%;border-collapse:collapse;background:var(--surface);border:1px solid var(--line);font-size:14.5px}
th{text-align:left;font-weight:600;font-size:12.5px;color:var(--muted);padding:10px 12px;border-bottom:1px solid var(--line);background:#F4F7F8;position:sticky;top:56px}
td{padding:10px 12px;border-bottom:1px solid #E6EBED;vertical-align:top}
tr:last-child td{border-bottom:0}
tbody tr:hover{background:#F7F9FA}
.iso{display:inline-block;padding:1px 7px;color:#fff;font-size:12px;font-weight:600;font-family:"IBM Plex Mono",monospace}
.count{font-family:"IBM Plex Mono",monospace;color:var(--muted)}
.nodata{color:#9AA7AD}

/* agent page */
.crumb{font-size:13.5px;color:var(--muted);margin-bottom:14px}
.ahead{background:var(--surface);border:1px solid var(--line);padding:26px 28px;margin-bottom:22px}
.ahead h1{margin:0 0 4px;font-size:32px;font-weight:600;letter-spacing:-.01em}
.alt{color:var(--muted);font-size:14px;margin-bottom:18px}
.facts{display:grid;grid-template-columns:repeat(auto-fit,minmax(150px,1fr));gap:0;border-top:1px solid var(--line)}
.fact{padding:14px 18px 14px 0;border-right:1px solid var(--line)}
.fact:last-child{border-right:0}
.fact dt{font-size:12px;color:var(--lead);margin-bottom:3px}
.fact dd{margin:0;font-size:15px;font-weight:500}
.tags{margin-top:16px;display:flex;gap:6px;flex-wrap:wrap}
.tag{background:var(--wash);color:var(--steel-d);font-size:13px;padding:3px 10px}
.panel{background:var(--surface);border:1px solid var(--line);margin-bottom:22px}
.panel>h3{margin:0;padding:14px 20px;border-bottom:1px solid var(--line);font-size:16px;font-weight:600;background:#F4F7F8}
.panel .body{padding:18px 20px}
.kv{display:grid;grid-template-columns:210px 1fr;gap:2px 18px;font-size:14.5px}
.kv dt{color:var(--muted);padding:7px 0}
.kv dd{margin:0;padding:7px 0}
.src{font-size:12px;color:var(--lead);font-family:"IBM Plex Mono",monospace}
.quote{font-size:13px;color:var(--muted);border-left:2px solid var(--line);padding-left:10px;margin-top:5px;font-style:italic;display:none}
tr.q .quote{display:block}
.qtoggle{background:none;border:0;color:var(--steel);font:inherit;font-size:12.5px;cursor:pointer;padding:0}
.cta{background:var(--ink);color:#DDE5E9;padding:22px 24px;margin:22px 0;display:flex;gap:24px;align-items:center;flex-wrap:wrap}
.cta p{margin:0;flex:1;min-width:260px;font-size:15px}
.cta strong{color:#fff;display:block;font-size:16px;margin-bottom:4px}
.cta a{background:var(--brass);color:#1A1205;padding:11px 20px;font-weight:600;font-size:14.5px;white-space:nowrap}
.cta a:hover{text-decoration:none;filter:brightness(1.08)}
.empty{background:var(--surface);border:1px dashed var(--line);padding:28px;color:var(--muted);font-size:14.5px}
.warn{background:#FBF3E0;border:1px solid #E5D3A8;padding:12px 16px;font-size:13.5px;margin-bottom:16px}
footer{border-top:1px solid var(--line);padding:28px 0 50px;font-size:13.5px;color:var(--muted)}
footer .wrap{display:flex;gap:30px;flex-wrap:wrap;justify-content:space-between}
.grid2{display:grid;grid-template-columns:1fr 1fr;gap:22px}
.grid2 .hrow{grid-template-columns:110px 1fr 44px;gap:10px;font-size:13.5px}
.areahead{font-size:13px;color:var(--lead);margin:22px 0 8px;border-bottom:1px solid var(--line);padding-bottom:5px}
.indrow{display:flex;justify-content:space-between;padding:7px 0;border-bottom:1px solid #E6EBED;font-size:14.5px}
.qcmatrix{overflow-x:auto}
.qcmatrix th.v{writing-mode:vertical-rl;transform:rotate(180deg);font-weight:500;padding:8px 4px;white-space:nowrap;height:150px;top:0}
.qcmatrix td.x{text-align:center;background:#DCE8E3;color:var(--patina);font-weight:700}

/* bubbles */
.toggle{display:inline-flex;border:1px solid var(--line);background:var(--surface);margin-bottom:16px}
.toggle button,.toggle a{border:0;background:transparent;font:inherit;font-size:13.5px;padding:8px 16px;cursor:pointer;color:var(--muted);text-decoration:none;display:inline-block}
.toggle button.on,.toggle a.on{background:var(--ink);color:#fff}
.bcrumb{font-size:13px;color:var(--muted);margin-bottom:10px;min-height:19px}
.bcrumb button{border:0;background:none;font:inherit;font-size:13px;color:var(--steel);cursor:pointer;padding:0}
.bmap.deep .bub{font-weight:600}
@keyframes bpop{from{opacity:0;transform:scale(.72)}to{opacity:1;transform:scale(1)}}
@keyframes bfade{from{opacity:0}to{opacity:1}}
.bmap.anim .bub{animation:bpop .34s cubic-bezier(.34,1.4,.5,1) backwards}
.bsmall.anim .bsm{animation:bfade .3s ease backwards}
.bcrumb.anim{animation:bfade .3s ease backwards}
@media(prefers-reduced-motion:reduce){.bmap.anim .bub,.bsmall.anim .bsm,.bcrumb.anim{animation:none}}
.untag{border:1px dashed var(--line);color:var(--muted);background:transparent;border-radius:50%;
  display:flex;align-items:center;justify-content:center;flex-direction:column;font-family:inherit;
  cursor:default;line-height:1.15;text-align:center;padding:0}

.bubbles{margin-top:34px}
.bmap{display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:10px}
.bub{border-radius:50%;display:flex;align-items:center;justify-content:center;flex-direction:column;
  color:#fff;cursor:pointer;transition:transform .14s;border:0;font-family:inherit;padding:0;line-height:1.1}
.bub:hover{transform:scale(1.06)}
.bub b{font-weight:600;display:block}
.bub i{font-style:normal;opacity:.8;font-weight:400}
.bub.sm{color:var(--ink);background:transparent!important}
.bsm{display:flex;align-items:center;gap:6px;border:1px solid var(--line);background:var(--surface);
  padding:4px 9px 4px 5px;font:inherit;font-size:12.5px;cursor:pointer;color:var(--muted)}
.bsm .dot{width:9px;height:9px;border-radius:50%}
.bsm:hover{border-color:var(--ink);color:var(--ink)}
.bwrap{display:flex;gap:14px;align-items:center;flex-wrap:wrap}
.bsmall{display:flex;gap:6px;flex-wrap:wrap;max-width:420px}
/* theranostics */
.thera{background:var(--surface);border:1px solid var(--line);margin-top:38px}
.thera .th{padding:16px 22px;border-bottom:1px solid var(--line);background:#F4F7F8;display:flex;justify-content:space-between;align-items:baseline;gap:14px;flex-wrap:wrap}
.thera .th h3{margin:0;font-size:17px;font-weight:600}
.thera .th span{font-size:13.5px;color:var(--muted)}
.pairs{display:grid;grid-template-columns:repeat(auto-fill,minmax(300px,1fr));gap:1px;background:var(--line)}
.pair{background:var(--surface);padding:15px 20px}
.pair .lig{font-size:12px;color:var(--lead);margin-bottom:8px}
.pair .two{display:flex;align-items:center;gap:10px;font-size:14.5px}
.pair .two .ar{color:var(--line);font-size:18px}
.pair .side{flex:1}
.pair .side .rl{font-size:11.5px;color:var(--lead);display:block}
/* indication split */
.splitcol{display:grid;grid-template-columns:1fr 1fr;gap:22px}
.splitcol h3{font-size:15px;margin:0 0 10px;font-weight:600;padding-bottom:6px;border-bottom:2px solid var(--ink)}
.splitcol .therapyhead{border-bottom-color:#4A4E7A}
@media(max-width:860px){.splitcol{grid-template-columns:1fr}.bsmall{max-width:100%}}




.ls{max-width:900px}
.card{background:var(--surface);border:1px solid var(--line);padding:22px 24px;margin-bottom:22px}
.card h3{margin:0 0 4px;font-size:18px;font-weight:600}
.card .cap2{color:var(--muted);font-size:14px;margin:0 0 18px;line-height:1.5}
.card .note{color:var(--lead);font-size:13px;margin:16px 0 0;line-height:1.5;border-top:1px solid var(--line);padding-top:12px}
.hrow{display:grid;grid-template-columns:180px 1fr 88px;gap:14px;align-items:center;padding:4px 0;font-size:14px}
.hrow .lb{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}
.hrow .n{text-align:right;font-family:"IBM Plex Mono",monospace;color:var(--muted);font-size:13px;white-space:nowrap}
.hrow .n em{font-style:normal;color:var(--lead);font-size:12px}
.hbar{height:17px;min-width:2px}
.dual{display:flex;height:26px;border:1px solid var(--line);font-size:12px;font-weight:600;color:#fff}
.dual span{display:flex;align-items:center;justify-content:center;overflow:hidden;white-space:nowrap}
.duallab{display:flex;justify-content:space-between;font-size:13px;color:var(--muted);margin:6px 0 20px}
.big2{font-size:34px;font-weight:600;line-height:1.1;letter-spacing:-.01em}
.big2 small{display:block;font-size:13.5px;color:var(--muted);font-weight:400;margin-top:5px;letter-spacing:0}
.kpi{display:grid;grid-template-columns:repeat(auto-fit,minmax(160px,1fr));gap:1px;background:var(--line);border:1px solid var(--line);margin-bottom:22px}
.kpi>div{background:var(--surface);padding:18px 20px}
.spark{display:flex;align-items:flex-end;gap:3px;height:78px;margin:6px 0 4px}
.spark i{flex:1;background:var(--steel);min-height:2px;display:block}
.spark i.dim{background:var(--line)}
.yrlab{display:flex;justify-content:space-between;font-size:12px;color:var(--lead)}
.doc{max-width:740px}
.doc h3{font-size:18px;margin:34px 0 10px;font-weight:600}
.doc h4{font-size:15px;margin:22px 0 6px;font-weight:600;color:var(--steel-d)}
.doc p{margin:0 0 13px;font-size:15.5px;line-height:1.62}
.doc ul{margin:0 0 14px;padding-left:20px;font-size:15.5px;line-height:1.6}
.doc li{margin-bottom:6px}
.doc .rule{background:var(--surface);border-left:3px solid var(--steel);padding:14px 18px;margin:0 0 18px;font-size:15px}
.doc .rule b{display:block;margin-bottom:4px}
.doc table{margin:8px 0 18px;font-size:14.5px}
.doc td:first-child{width:46%;font-weight:500}

.badge{display:inline-flex;align-items:center;gap:5px;font-size:11.5px;font-weight:600;padding:2px 8px;
  letter-spacing:.01em;white-space:nowrap;vertical-align:2px}
.badge .d{width:7px;height:7px;border-radius:50%}
.b-mono{background:#DCE8E3;color:#2A5548}
.b-lit{background:#E1E7EA;color:#1D4256}
.b-drv{background:#FBF3E0;color:#7A5B14}
.legend{display:flex;gap:18px;flex-wrap:wrap;font-size:13px;color:var(--muted);margin:0 0 16px;
  background:var(--surface);border:1px solid var(--line);padding:12px 16px}
.legend span{display:inline-flex;align-items:center;gap:7px}
.legend i{width:9px;height:9px;border-radius:50%;display:block}
.basis{font-size:12.5px;color:var(--lead);line-height:1.5;margin-top:12px;border-top:1px solid var(--line);padding-top:10px}
tr.prelim td:first-child{box-shadow:inset 3px 0 0 #E0B94E}
.sbwrap{position:relative}
.sugg{position:absolute;left:0;right:0;top:100%;background:var(--surface);border:1.5px solid var(--ink);border-top:0;z-index:30;max-height:340px;overflow:auto}
.sugg div.it{padding:9px 15px;cursor:pointer;display:flex;gap:10px;align-items:baseline;border-bottom:1px solid #EDF1F2}
.sugg div.it:last-child{border-bottom:0}
.sugg div.it.sel,.sugg div.it:hover{background:var(--wash)}
.sugg .nm{flex:1;font-size:15px}
.sugg .why{font-size:12px;color:var(--lead)}
.sugg .kind{font-size:11px;color:#fff;padding:1px 6px;font-family:"IBM Plex Mono",monospace}
mark{background:#F6E6B8;color:inherit;padding:0 1px}
.sres{font-size:13px;color:var(--muted);margin:-8px 0 16px}
.suphead{display:grid;grid-template-columns:repeat(auto-fit,minmax(140px,1fr));border-top:1px solid var(--line)}
.bars{background:var(--surface);border:1px solid var(--line);padding:20px 22px;margin-bottom:24px}
.barrow{display:grid;grid-template-columns:190px 1fr 54px;gap:12px;align-items:center;padding:5px 0;font-size:14px}
.barrow .t{background:var(--steel);height:16px;min-width:2px}
.barrow .t.other{background:var(--lead)}
.barrow a{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}
.barrow .n{text-align:right;font-family:"IBM Plex Mono",monospace;color:var(--muted);font-size:13px}
.contrib{background:var(--surface);border:1px solid var(--line);padding:22px 24px;margin-top:26px;display:flex;gap:22px;align-items:center;flex-wrap:wrap}
.contrib p{margin:0;flex:1;min-width:280px;font-size:14.5px;color:var(--muted)}
.contrib strong{color:var(--ink);display:block;font-size:15.5px;margin-bottom:4px;font-weight:600}
.contrib a{border:1.5px solid var(--ink);color:var(--ink);padding:10px 18px;font-weight:600;font-size:14px;white-space:nowrap}
.contrib a:hover{background:var(--ink);color:#fff;text-decoration:none}
@media(max-width:700px){.hrow{grid-template-columns:120px 1fr 70px;gap:10px;font-size:13px}.grid2 .hrow{grid-template-columns:96px 1fr 40px}}
@media(max-width:860px){.doors{grid-template-columns:1fr}.grid2{grid-template-columns:1fr}.kv{grid-template-columns:1fr}.facts{grid-template-columns:1fr 1fr}}